Sinisa Mihajlovic's team have won only one of their last seven matches against the visitors, while I Bianconeri are unbeaten in their last four meetings with the home side.
Bologna extended their winless run to seven league games last weekend as they played out a goalless draw away at Fiorentina.
Despite having more possession, Sinisa Mihajlovic's side struggled to break down the Florence outfit, who failed to have a single shot on target.
I Rossoblu have now drawn their last four league matches, having not drawn any of their first 11 league games this season before this run.
One positive to take away was a clean sheet for only the second time this campaign – only Genoa and Sampdoria have kept fewer.
Mihajlovic will be aware that his side could slip into a precarious position if their winless run were to continue and hopes to secure the three points on Wednesday, which would end that run and could move Bologna eight points clear of the relegation zone.
Udinese have suffered successive league defeats as their 2-0 home loss to Benevento was followed by a 4-1 defeat away at Juventus last weekend.
Defeat in Turin was Udinese's seventh of the season in Serie A, which has seen them drop to 14th in the table, just four points above the relegation zone.
Manager Luca Gotti has seen his side struggle to score goals this campaign, with I Bianconeri scoring just 15 times so far – only Parma have scored fewer with 13.
Gotti is hoping that his attacking players can find their form in front of goal before they get dragged into a relegation battle.
Victory on Wednesday would be Udinese's fifth of the campaign and could move them as high as 10th in the table.
Bologna Serie A form: LLDDDD
Udinese Serie A form: WWDDLL
Former Watford pair Gerard Deulofeu (ankle) and Stefano Okaka (thigh) both remain out with injuries, while wing-back Thomas Ouwejan could return to the matchday squad after testing negative for coronavirus last week.
Bologna possible starting lineup:
Da Costa; De Silvestri, Danilo, Tomiyasu, Hickey; Schouten, Svanberg; Orsolini, Soriano, Barrow; Palacio
Udinese possible starting lineup:
Musso; Becao, De Maio, Samir; Larsen, De Paul, Walace, Pereyra, Zeegelaar; Pussetto, Lasagna
We say: Bologna 1-1 Udinese
Bologna have only failed to score in one of their seven home league matches this campaign, while Udinese have scored 10 times in seven games on the road. A tight encounter is expected on Wednesday afternoon and so a draw could be on the cards.