Two unanswered goals from Rodrigo Palacio last week have put Inter Milan in command of this tie ahead of their trip to Romania on Thursday night.
The Argentine was only on the pitch because of a knee injury suffered to his fellow countryman Diego Milito. Scans have since revealed that Milito will play no part against Cluj and will actually miss the rest of the season.
Despite Milito's absence, Inter have a positive record in the Eastern European nation. From three trips, they've won all three matches and haven't conceded a goal.
In contrast, Cluj have faced Italian opposition twice on home soil, but have failed to win on either occasion.
The home side are likely to come up against one of their former players in Alvaro Pereira, who left Cluj for Porto in 2009. During his stint with the club he won the Romanian Cup.
The winner of this tie will face either Tottenham Hotspur or Lyon in the last 16 of the competition.
Recent form
Cluj: DWLWWL
Inter: LDLWWL
Possible starting lineups
Cluj: Felgueiras; Rada, Cadu, Sepsi, Piccolo; Pinto, Muresan, Godemeche, Camora; Rui Pedro, Maah
Inter: Handanovic; Silvestre, Nagatomo, Pereira, Ranocchia; Cambiasso, Gargano, Guarin, Kovacic; Cassano, Palicio
Sports Mole says: 2-1