The match comes just two weeks after City hammered the same opposition 6-0 in the Premier League, and the holders will once again go into the game as favourites to retain the trophy.
Chelsea boss Maurizio Sarri finds himself under increasing pressure following a wildly inconsistent spell of form and could face more questions over his future if his side are beaten again at Wembley.
Here, Sports Mole selects its strongest combined XI from both squads, using only players available for Sunday's match.
Ederson may not start at Wembley due to Pep Guardiola's preference of using Arijanet Muric in this competition, but with Kepa Arrizabalaga a doubt due to injury the Brazilian is the clear choice to get the gloves in this XI.
Considering Chelsea conceded six times in this fixture just two weeks ago, it is perhaps surprising that they contribute two defenders from the back four, although Cesar Azpilicueta remains one of the most consistent defenders in England while Marcos Alonso's selection is as much down to a lack of other options with Benjamin Mendy still injured.
Aymeric Laporte is another option for the left, but his best position is at centre-back and he is joined by Nicolas Otamendi, who benefits from doubts over John Stones's fitness. Kyle Walker, Vincent Kompany and Antonio Rudiger were also in contention for a place in that defensive quartet, but all narrowly miss out.
It is an all-Man City midfield trio, with Kevin De Bruyne now back at full fitness and joining David Silva as the chief creators for Man City once again. Much has been made of N'Golo Kante's new role at Chelsea, but in an attacking sense the Frenchman is nowhere near the level of the Man City duo.
Kante is closer to making the team in his former position of defensive midfield, but Fernandinho's importance to Man City has really been highlighted this season and the Brazilian is a sure-fire pick above Jorginho, whose performances have come under intense scrutiny recently.
Bernardo Silva is very unfortunate to miss out on a place in this team having established himself as one of Guardiola's most trusted players this season, but the level of competition in the front three is incredible with the likes of Leroy Sane, Willian and Gonzalo Higuain also failing to make the XI.
Sergio Aguero leads the line having reaffirmed his position as City's apex striker this season, and he has a particularly good record against Chelsea with his hat-trick in the Premier League meeting earlier this month taking him to 15 goals against the Blues.
Raheem Sterling has been a similarly high performer for City this season, with 12 goals and nine assists in the Premier League alone, while Eden Hazard can top even that tally despite Chelsea's comparative struggles with 10 assists to go with his 12 goals.