With third position having been effectively secured with a 1-1 draw with Leicester City earlier this week, Tuchel can approach the game with sentiment and resting over-used players as his priority.
Antonio Rudiger should start ahead of a switch to Real Madrid, while Cesar Azpilicueta and Marcos Alonso are in line to play at a time when speculation persists regarding potential transfers to Barcelona.
Second-choice goalkeeper Kepa Arrizabalaga is another who may be selected for similar reasons, but it remains to be seen whether Andreas Christensen will be provided with the same level of respect after his recent late withdrawals from the squad.
If Thiago Silva is rested, Rudiger could move into the centre of the back three to accommodate Malang Sarr, while Saul Niguez may replace N'Golo Kante in midfield before returning to parent club Atletico Madrid.
Tuchel is unlikely to risk Timo Werner's hamstring injury, while Ben Chilwell and Callum Hudson-Odoi are already pencilled in to make early returns for pre-season training after their respective knee and Achilles injuries.
Chelsea possible starting lineup: Arrizabalaga; Azpilicueta, Rudiger, Sarr; James, Saul, Loftus-Cheek, Alonso; Ziyech, Mount; Havertz