The champions have been in imperious form since resuming their campaign after lockdown, cruising past Arsenal and Burnley while scoring eight goals without reply in the process.
Pep Guardiola's side have prolonged their title reign as a result, but know that any slip-up in West London could hand Liverpool the trophy before the top two meet on July 2.
Here, Sports Mole looks at how Man City could line up for the contest.
Man City's faultless return in terms of form has not quite been matched in terms of fitness, and club-record goalscorer Sergio Aguero could miss the remainder of the season after aggravating a knee injury against Burnley.
The Argentine will visit a specialist in Barcelona but is expected to undergo surgery which could ensure that he does not play again in 2019-20, leaving Gabriel Jesus to lead the line.
Mahrez's brace against Burnley may be enough to earn him another start on Thursday, but Silva may be rested and Phil Foden, who also scored twice on Monday night, will hope to be handed another start too.
Guardiola named an entirely different back four in both games so far and could return to the unit which faced Arsenal - minus Eric Garcia, who is still unable to play due to concussion protocols.
> Click here to see how Chelsea could line up for this contest body check tags ::