Napoli have rested Gonzalo Higuain for their Europa League tie away at Club Brugge.
The Italian side, who have already progressed from Group D, have made eight changes in total from the side that won 2-0 against Hellas Verona at the weekend.
The only players to survive are Vlad Chiriches, Marek Hamsik and Jose Callejon.
Club Brugge have also made a number of changes from the side that lost 3-1 to FC Midtjylland three weeks ago.
Brandon Mechele, Davy de Fauw, Ruud Vormer, Jose Izquierdo and Jelle Vossen are the five new faces brought in by Michel Preud'homme.
Club Brugge: Bruzzese; Meunier, Mecehele, Denswil, De Fauw; Simons, Vormer, Vazquez, Izquierdo; Vossen, Gedoz
Subs: Bolat, Castelletto, Bollingoli, Vanaken, Claudemir, Pereira, Diaby
Napoli: Gabriel; Maggio, Chiriches, Koulibably, Strinic; Lopez, Valdifiori, Chalobah; Hamsik, Callejon, El Kaddouri
Subs: Rafael, Gionta, Hysaj, Allan, Negro, Ghoulam, Luperto
