Frankfurt, meanwhile, will compete in the Europa League next season after their Champions League hopes were ended last weekend.
It has been a disappointing end to the season for Frankfurt, whose form has deteriorated since their manager Adi Hutter revealed that he will be leaving the club to replace Marco Rose at Borussia Monchengladbach in the summer.
After beating Champions League qualification rivals Borussia Dortmund 2-1 on April 3, Frankfurt looked near certainties to qualify for Europe's elite competition for the first time in the club's history.
However, a combination of BVB winning six league games in a row and Frankfurt losing three of their last five has meant that they will instead have to settle for Europa League football next season.
Last weekend's 4-3 defeat to already-relegated Schalke 04 was a particularly disappointing result given that a win would have kept them in the hunt heading into the final day against Freiburg. Instead, it is essentially a dead rubber for them, with Hutter hoping to depart the club on a high after a successful three-year spell.
Freiburg, meanwhile, head to Frankfurt sitting outside of the top half despite earning a credible point from their 2-2 draw with champions Bayern Munich last weekend.
Manuel Gulde and Christian Gunter, who has been one of the Bundesliga's finest left-backs this season and has deservedly earned a spot in Germany's Euro 2020 squad as a result, pegged Bayern back on two occasions to keep their hopes of qualifying for Europe alive.
Christian Streich's side are two points behind Union Berlin, who currently occupy the inaugural Europa Conference League position, so they must beat Frankfurt to have any chance of leapfrogging the three sides above them in the table and assume that position.
As such, Streich is likely to employ an attacking gameplan on Saturday, which could create a highly entertaining match.
Jabez Makanda remains out due to a broken ankle.
Freiburg, meanwhile, will be without the suspended Roland Sallai after the Hungary winger picked up his fifth caution of the season.
Eintracht Frankfurt possible starting lineup:
Trapp; Tuta, Hinteregger, N'Dicka; Chandler, Ilsanker, Hasebe, Kostic; Kamada, Younes; Silva
Freiburg possible starting lineup:
Flekken; Kubler, Lienhart, Gulde, Gunter; Schmid, Hofler, Santamaria, Grifo; Demirovic, Holer
We say: Eintracht Frankfurt 2-2 Freiburg
We can envisage a highly entertaining encounter in Frankfurt on Saturday between two sides who are likely to adopt attacking mindsets.
Freiburg must win to have a chance of qualifying for Europe, but Frankfurt are unlikely to want to let Hutter down in his last game in charge and have nothing to lose.
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