Wycombe finished third in the table after clubs voted to end the season early and settle each position on a points-per-game basis, while Fleetwood claimed sixth place.
Wanderers were arguably the big winners of the League One campaign being ended 11 games early as they were eighth in the division at the time of the coronavirus-enforced shutdown.
However, they replaced Peterborough United in the playoffs thanks to their superior points-per-game record, having played one game fewer than the Posh.
The Chairboys had been top of the division for a while around the turn of the year, only to slip down the table following a run of five wins from 11 matches.
Finishing in the playoffs is a superb achievement for Gareth Ainsworth, though, having transformed his side from League Two relegation candidates to League One promotion hopefuls.
Ainsworth will now be looking to maintain Wanderers' upwards momentum by guiding them into the second tier following a 16-year absence.
Wycombe's form on their travels has been pretty poor, however, having lost six of their last seven away from Adams Park, where the second leg will take place on Monday.
Fleetwood will therefore be looking to lay down a marker at Highbury, albeit without any of their supporters in attendance, with Joey Barton's side unbeaten in 12 at home.
No wonder, then, that Barton is "supremely confident" his side can overcome Wycombe and book a place in the final, which is scheduled to take place at Wembley on July 13.
Town have been in and around the playoffs for the vast majority of the season, but they only marginally edged out Peterborough to secure a place in the end-of-season lottery.
Now they are just three games away from booking a place in the Championship for the first time in their history, an achievement that will see Barton go down in club folklore.
Fleetwood's League One form: WWDWDD
Wycombe's League One form: LWLWWL
The prolonged gap between games means that Fleetwood have a fully-fit squad to choose from on Friday.
Wycombe are unable to call upon full-back Jason McCarthy as he has returned to parent club Millwall since their most recent outing - a 3-1 loss to Doncaster Rovers on February 29.
Fleetwood possible starting lineup:
Eastham; Coyle, Gibson, Souttar, Andrew; Connolly, Whelan, Coutts; Burns, Evans, McKay
Wycombe possible starting lineup:
Allsop; Jombati, Charles, Stewart, Jacobson; Freeman, Gape, Thompson; Samuel, Akinfenwa, Wheeler
We say: Fleetwood 2-1 Wycombe
Fleetwood took four points off Wycombe during the regular season and boast the joint-best home record in League One this term, so we are backing Barton's men to take a slender lead into next week's reverse fixture.