Jocelyn Gourvennec has made two changes to the Guingamp side that lost 2-0 at Lyon last time out.
Jonathan Martins Pereira and Claudio Beauvue are demoted to the bench, while Dorian Leveque and Thibault Giresse come in.
Lille boss Rene Girard has made three changes to his side following their 2-0 win over the then-unbeaten AS Monaco on Sunday.
Franck Beria, Jonathan Delaplace and Soualiho Meite all come into the team, while Florent Balmont, Idrissa Gueye and Ronny Rodelin all drop out of the side.
Guingamp: N'dy Assembe, Lemaitre, Leveque, Sorbon, Kerbrat, Mathis, Sankhare, Atik, Giresse, Mandanne, Yatabare
Lille: Enyeama, Basa, Beria, Kjaer, Sidibe, Souare, Delaplace, Mavuba, Meite, Kalou, Roux