Schalke 04 coach Huub Stevens has named Klaas-Jan Huntelaar and Ibrahim Afellay in a three-pronged attack for the visit to 14th-placed Hoffenheim.
Huntelaar has Afellay on the left flank for support, with Jefferson Farfan attacking down the right-hand side.
For the hosts, Joselu leads the line with Kevin Volland supporting him in the number 10 position, looking to add to his four league assists already this term.
Hoffenheim: Wiese; Beck, Compper, Johnson, Vestergaard; Rudy, Williams, Usami, Firmino; Volland; Joselu
Schalke: Unnerstall; Howedes, Uchida, Fuchs, Matip; Neustadter, Holtby, Jones; Farfan, Afellay, Huntelaar