Grant McCann's side are enduring a dire run of form that has seen them slip down the Championship table to within seven points of the relegation zone.
Hull have not won any of their last nine matches across all competitions, losing seven times - including a run of five defeats in a row.
After a shaky start, Hull had been enjoying a steady season and looked set to cruise to a mid-table finish, but their recent form could see them dragged into a relegation battle if their slide is not arrested soon.
McCann's side were beaten 3-1 in Barnsley in the reverse fixture earlier this season, and will hope to avoid a repeat at home this time around.
However, their record at the KCOM Stadium has been woeful this term, managing just six wins from 17 home games so far. Only Reading and Huddersfield Town have recorded fewer points at home than Hull's total of 21.
Barnsley, though, have been dreadful on the road themselves, picking up just nine points from their 16 Championship away games this season, losing 11 times.
The newly-promoted outfit are one point and one place ahead of bottom-of-the-league Luton Town, but are on an upward trajectory as they look to maintain their Championship status.
Despite their back-to-back clean sheets, Barnsley still hold the second-worst defensive record in the division, shipping 58 goals in just 34 games.
Hull City Championship form: LLDLDL
Barnsley Championship form: LLDLWW
Hull manager McCann has a lengthy injury list to contend with, and is particularly short on strikers heading into the clash with Barnsley.
Barnsley boss Struber has a far greater pool of players to choose from, but also must deal with an unusual absence.
Meanwhile, Bambo Diaby has been suspended by the club amidst an allegation of doping that is being investigated by the FA.
Hull City possible starting lineup:
Long; Pennington, Burke, De Wijs, Elder; Lopes, Irvine; Wilks, Toral, Honeyman; Magennis
Barnsley possible starting lineup:
Collins; Sollbauer, Halme, Williams; Ludewig, Bahre, Mowatt, Oduor; Woodrow; Brown, Chaplin
We say: Hull City 1-1 Barnsley
Hull are poor at home and Barnsley - despite their recent upsurge in form - have a terrible record on the road. These two sides could cancel each other out in a score draw at the KCOM Stadium.