With both sides vying for a playoff spot, the game has all the makings of an enthralling affair as the season reaches its final knockings.
Atlanta United were denied a fourth league victory on the bounce following a 1-0 loss to Philadelphia Union at Subaru Park on Saturday.
The Five Stripes missed out on an opportunity to climb up into seventh place but remain just a point adrift of the last playoff place in the Eastern Conference.
Their next task comes against an opposing side who are unbeaten in each of the last five meetings between the teams in the last 12 months.
With a clash against seventh-placed Montreal to follow, Thursday's hosts will want to stay within touching distance ahead of what is set to be a season-defining clash.
Inter Miami suffered a second consecutive home defeat in the space of five days on Thursday when they were thrashed 5-1 by Nashville SC.
Hany Mukhtar found the back of net twice against Gary Neville's men, and he was joined on the scoresheet by Walker Zimmerman, Randall Leal and Alistair Johnston, with Gonzalo Higuain scoring his side's only goal of the contest.
Consequently, the Herons have dropped to 10th position in the standings, four points behind their next opponents albeit with a game in hand.
Thursday's visitors, who picked up 16 of 18 points available between August 19 and September 15, will be aiming to rediscover their midas touch.
Jorge Figal has served a one-game ban for picking up a red card in the visitors' defeat to New York Red Bulls and the Argentine is eligible for selection once again.
However, Gregore is suspended for Thursday's fixture after the 27-year-old receiving his marching orders versus Nashville last time out.
Having registered in each of his last three outings on home turf, Ezequiel Barco will be looking to put on another impressive display in attack.
Josef Martinez played no part in Atlanta's last involvement, but the forward is expected back in the starting XI for this one to partner the aforementioned Barco.
Atlanta United possible starting lineup:
Guzan; Walkes, Robinson, Campbell; Bello, Moreno, Sosa, Lennon, Rossetto; Barco, Martinez
Inter Miami possible starting lineup:
Marsman; Makoun, Figal, Pirez; Morgan, Chapman, Matuidi, Shea; Robinson, Pizarro, Higuain
We say: Atlanta United 2-1 Inter Miami
The onus is more on Atlanta United to seize the initiative and claim all three points in front of their fans while Inter Miami go in search of a quick response to an embarrassing defeat last time out.
We expect an open and entertaining affair with the home side just edging it by the odd goal come the full-time whistle.
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