Genoa vs. Udinese (Saturday, 2.00pm)
Having sacked their high-profile head coach, the hosts will hope for a reaction under new management against a side still struggling despite their own change in the dugout.
We say: Genoa 1-1 Udinese
Five of the last eight encounters between these clubs has ended level, and the same outcome could be in store on Saturday, with either side low on confidence and lacking punch in the final third.
Genoa's hunt for a sense of direction goes on under their intriguing new manager, while the visitors can add another point towards building a total that secures Serie A survival.
Inter Milan vs. Venezia (Saturday, 5.00pm)
Having seen their eight-match Serie A success streak ended by a goalless draw last weekend, the Nerazzurri went on to progress in the Coppa Italia, while their Venetian visitors salvaged a first point of the year in their clash with Empoli.
We say: Inter Milan 2-0 Venezia
A repeat of the 2-0 defeat they inflicted on Venezia a few weeks ago is a strong possibility on Saturday evening, as Inter were able to rest many of their main men in midweek.
The champions are virtually unassailable at San Siro, and with goals coming from all quarters, they should be cruising to victory before the game reaches its climax.
Lazio vs. Atalanta (Saturday, 7.45pm)
Two of Calcio's most entertaining teams convene in the capital, having racked up 90 league goals between them this term - including four during a dramatic draw in October's reverse fixture.
We say: Lazio 1-2 Atalanta BC
Though goals have started to dry up since Duvan Zapata was struck down by injury - at least by their own free-scoring standards - Atalanta can edge out their hosts at the Olimpico thanks to a squad with several attacking options.
While Lazio are equally adept at finding the net, much relies on a few key cogs to turn smoothly, and the combination of defensive lapses and some integral absences could tilt the balance in their visitors' favour.