Spezia vs. Napoli (Sunday, 11.30am)
After securing their top-flight status last weekend, Spezia host Napoli in the early kickoff on the final day of the Serie A season.
Aquilotti can finish no lower than 16th in the table, while Gli Azzurri have battled for the title this term but are guaranteed to finish third.
We say: Spezia 0-2 Napoli
Napoli are ending the campaign in good form and depending on how strong Luciano Spalletti decides to go with his team selection, they should finish with three points here. With their survival confirmed, Spezia are unlikely to provide that much of a challenge.
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Inter Milan vs. Sampdoria (Sunday, 5.00pm)
Reigning champions Inter Milan could be 90 minutes away from retaining their Serie A title on Sunday, if they can claim maximum points against final-day opponents Sampdoria at San Siro.
While city rivals Milan remain favourites for the Scudetto due to a two-point advantage, Inter must still win and hope for their Rossonero rivals to slip up in Sassuolo.
We say: Inter Milan 2-0 Sampdoria
Eleven goals in their last three games - including 30 minutes of Coppa Italia final extra time - suggests that Inter are holding nothing back in their pursuit of the double.
It would take an improbable turn of events for Sampdoria to deprive them of three points on Sunday, so they will take care of business at San Siro and await news from Sassuolo's Mapei Stadium with bated breath.
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Sassuolo vs. AC Milan (Sunday, 5.00pm)
Just 90 minutes away from finally reclaiming the Scudetto, AC Milan know that a draw against Sassuolo on Sunday evening would secure their first Serie A title in over a decade.
Leading reigning champions Inter by two points ahead of an absorbing season's grand finale, the Rossoneri also have the better head-to-head record between the second city rivals, so must merely avoid defeat to be crowned kings of Calcio for a 19th time.
We say: Sassuolo 1-2 AC Milan
Only Inter have attempted more shots than Sassuolo (299) and AC Milan (296) in the second half of this Serie A season, so in normal circumstances, this encounter may be an open affair with a series of chances at either end.
While the home side rarely hold anything back, thanks to the potency of their four-man forward line, the Rossoneri have their eyes fixed on the main prize and are likely to take a relatively cautious approach - which has often served them well as they moved to within touching distance of the Scudetto. It is their pace and power on the counter which could ultimately prove decisive.
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Salernitana vs. Udinese (Sunday, 8.00pm)
Salernitana will be looking to secure their spot in next season's Serie A when they finish their 2021-22 campaign at home to Udinese on Sunday night.
I Granata are currently 17th in the table, two points clear of 18th-placed Cagliari, while Udinese occupy 12th position, which is the highest they can finish this term.
We say: Salernitana 1-0 Udinese
Salernitana need to win to be sure of a spot in next season's Serie A, and we are backing the home side to triumph here. Udinese do not have too much to play for on the final weekend, and Nicola's team have been in impressive form in recent weeks.
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Venezia vs. Cagliari (Sunday, 8.00pm)
Previously billed as a relegation decider, Sunday's clash between Serie A strugglers Venezia and Cagliari instead sees the former already demoted, and their visitors require victory to stand a chance of not joining them.
Stadio Pier Luigi Penzo will bid a fond farewell to the top flight after just one season, as the home side seek a win which could prevent them finishing bottom of the standings - but their Sardinian counterparts' need is far greater.
We say: Venezia 1-2 Cagliari
Though their predicament is precarious, Cagliari at least face a side doomed to demotion and weakened by yet more suspensions, as they search for a crucial away win.
With little to play for, except signing off their Serie A adventure in front of their fans, Venezia may be outfought in their individual battles and ultimately lose - but even victory for the visitors must be accompanied by good news from Salerno if they are to pull off a great escape.
