The Old Lady dropped to second spot in the table with a 2-2 draw at home to Sassuolo last weekend.
Maurizio Sarri's side are yet to lose in Italy's top flight this season, winning 11 and drawing three of their 14 league fixtures to collect 36 points.
Lazio have won each of their last six in Serie A, though, and will provide strong competition for the Italian champions this weekend.
Here, Sports Mole looks at how the Turin giants could line up in Rome on Saturday night.
Giorgio Chiellini, Marko Pjaca, Sami Khedira and Douglas Costa are all still on the sidelines fore Juve, while Adrien Rabiot remains a doubt due to an adductor issue.
Sarri is expected to shuffle his pack from the clash with Sassuolo, but Aaron Ramsey has been ruled out of this weekend's clash with a thigh issue, meaning that Federico Bernardeschi is likely to keep his spot.
Wojciech Szczesny and Blaise Matuidi are in line to replace Gianluigi Buffon and Emre Can, though, while Paulo Dybala could also be handed a spot in the final third at the expense of Gonzalo Higuain, with the pair sharing the spot alongside Cristiano Ronaldo this term.
Ronaldo has struggled to overcome a troublesome knee injury in recent weeks, but the Portugal international is fit to start Saturday's clash in Rome.