Here, Sports Mole look at how Juve could line up for Wednesday's showdown.
Maurizio Sarri could make a handful of changes after the Bianconeri's comfortable outing against Udinese in their last game, restoring a few regulars to the starting lineup.
Szczesny could recover from his shoulder complaint to reclaim his starting spot between the sticks ahead of Gianluigi Buffon, while regular full-backs Alex Sandro and Juan Cuadrado could replace Mattia De Sciglio and Danilo respectively.
Matthijs de Ligt will also hope to return to the side ahead of Merih Demiral and start alongside experienced defender Leonardo Bonucci at the heart of the back four. Bonucci had to be replaced in the last game due to a head injury but it should not prevent him from featuring in this one.
In midfield, Miralem Pjanic will expect to resume his spot at the base of the diamond ahead of Rodrigo Bentancur, while there could be minutes afforded to Aaron Ramsey, with Adrien Rabiot having enjoyed a short run in the side. Blaise Matuidi should continue on the left of the four.