Rabbi Matondo could make his Stoke debut against Leicester after joining on loan from Schalke.
The Wales international has signed on loan in time to feature in Saturday's FA Cup third round tie.
Striker Vardy has a long-standing hip problem while midfielder Maddison suffered a knee injury in the win at Newcastle.
Ricardo Pereira (groin) has returned to training but will not feature but fellow defender Caglar Soyuncu (groin) is available for the Foxes.
Roma loanee Cengiz Under is a doubt after the winger picked up an ankle knock.