PSG vs. Brugge (Tuesday, 5.45pm)
Already guaranteed to finish second in Champions League Group A, Paris Saint-Germain round off their group stage fixtures with the visit of Club Brugge on Tuesday night.
Les Parisiens fell to a 2-1 defeat to Manchester City on matchday five, while their Belgian counterparts were hit for five against RB Leipzig.
We say: Paris Saint-Germain 3-1 Club Brugge
Shipping 14 goals in their last three Champions League games - as well as at least two in their last seven in all tournaments - is seemingly a recipe for disaster for Brugge, but PSG have not exactly been ruthless in recent days.
Some expected alterations on the hosts' end could also have Clement's side stepping out onto the turf with a sense of optimism, but Pochettino's men will still expect to march to a routine win in front of their own fans.
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> How PSG could line up against Club Brugge
RB Leipzig vs. Man City (Tuesday, 5.45pm)
Already guaranteed to finish at the top of the pile in Champions League Group A, Manchester City travel to RB Leipzig for matchday six on Tuesday evening.
Pep Guardiola's men saw off Paris Saint-Germain 2-1 last time out, while their German hosts put five unanswered goals past Club Brugge.
We say: RB Leipzig 1-2 Manchester City
Leipzig's prospects of finding the back of the net are always high with Nkunku leading the charge and the new manager bounce potentially in tow, and City have been uncharacteristically leaky at the back in Europe so far this term.
Guardiola will not allow his side to take their foot off the gas even with qualification assured, though, and with several fringe players hoping to impress, the Premier League champions ought to prevail by a narrow margin.
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> How Man City could line up against RB Leipzig
> Man City injury, suspension list vs. RB Leipzig
AC Milan vs. Liverpool (Tuesday, 8.00pm)
Liverpool will aim to make it six wins from six in the 2021-22 Champions League when they pay a visit to San Siro to lock horns with AC Milan on Tuesday night.
Jurgen Klopp's dominant crop are already assured of their place in the last 16, while the Rossoneri are involved in a three-way battle for second place in Group B.
We say: AC Milan 2-1 Liverpool
An inexperienced Liverpool side playing on the San Siro turf for the first time may just come up short this week, especially with Pioli's side having much more to fight for in midweek.
Very rarely are the Reds kept at bay no matter who leads the line, but the Rossoneri's settled XI can follow up their hard-fought Wanda Metropolitano win with a victory that may or may not be enough for a spot in the knockout rounds.
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> How Liverpool could line up against AC Milan
> Liverpool injury, suspension list vs. AC Milan
Porto vs. Atletico (Tuesday, 8.00pm)
Both still vying for a second-placed finish in Champions League Group B, Porto and Atletico Madrid prepare for battle at the Estadio do Dragao on Tuesday night.
The hosts currently occupy the second and final qualifying spot for the knockout stages, but Atletico - and AC Milan - are just one point adrift of Sergio Conceicao's side.
We say: Porto 1-1 Atletico Madrid
Atletico's defensive woes are there to be exposed by Porto this week, and the Portuguese hosts would choose no better time to find their shooting boots in Europe after some previous profligacy.
Both teams have a desperate need for points on Tuesday, but Atletico have plenty of experienced names used to high-pressure situations such as this one and ought to take a point back home to Madrid, although that result would not exactly benefit either side's hopes of securing second.
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Dortmund vs. Besiktas (Tuesday, 8.00pm)
Already out of contention for a last-16 place, Borussia Dortmund welcome eliminated Besiktas to the Westfalenstadion on Tuesday, in the Champions League.
While Dortmund will finish third in Group C, and enter the Europa League playoffs regardless of the result, their Turkish counterparts are destined for fourth following a pointless first five matchdays.
We say: Borussia Dortmund 3-1 Besiktas
Though their Champions League campaign has faltered - and defeat in Der Klassiker was another sucker punch at the weekend - Dortmund have scored freely this season and should prise open a flimsy Besiktas rearguard on several occasions.
The Turkish champions' slump shows little sign of coming to an end too, so they will finish the group stage without a point - allowing them to return their thoughts to domestic concerns.
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Ajax vs. Sporting Lisbon (Tuesday, 8.00pm)
Group C winners Ajax will aim to maintain their flawless Champions League record on Tuesday, as they welcome fellow last-16 qualifiers Sporting Lisbon to Amsterdam.
The two national champions have already reached the knockout stages, and reconvene on the final matchday of the group phase after the Dutch champions' crushing victory in the Portuguese capital.
We say: Ajax 2-2 Sporting Lisbon
With the top two settled in Group C, both teams can take a free run at this intriguing encounter, which should be a much closer affair than the one-sided first meeting back in September.
Thanks to an abundance of pace and trickery, either side is adept at making opponents pay in the final third, so an open game should end in a score draw.
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Real Madrid vs. Inter Milan (Tuesday, 8.00pm)
Real Madrid and Inter Milan will lock horns at Bernabeu in the Champions League on Tuesday evening, with first position in Group D on offer for both sides.
Los Blancos are currently top of the section, two points clear of second-placed Inter, with both teams already advancing to the knockout stage of the competition.
We say: Real Madrid 1-1 Inter Milan
A point is enough for Real Madrid to secure first spot in the section, and we can see a low-scoring draw in this match. Ancelotti will make changes from the side that started against Real Sociedad, but Los Blancos should still be strong enough to hold the Italian champions to a score draw in the Spanish capital.
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> How Real Madrid could line up against Inter Milan
> Real Madrid injury, suspension list vs. Inter Milan
Shakhtar vs. Sheriff Tiraspol (Tuesday, 8.00pm)
Shakhtar Donetsk will be looking to end a disappointing 2021-22 Champions League group-stage campaign on a positive note when they welcome Sheriff Tiraspol on Tuesday night.
The Ukrainian giants have only picked up one point from their five Group D matches this season, which will see them finish bottom of the section, with Sheriff already making sure of third spot.
We say: Shakhtar Donetsk 1-1 Sheriff Tiraspol
Shakhtar will be desperate to end their 2021-22 European campaign on a winning note, but Sheriff have proved their credentials in the Champions League this season, and we can see the Moldovan outfit claiming a point on Tuesday night to round off a very successful group stage.
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