Barcelona have played host to English clubs at the Camp Nou on 27 occasions, but just one side has returned home with a victory.
That club is Liverpool, who won in Catalonia back in 1976 and then again in 2007.
If Manchester City are to remain in this season's Champions League, they must match their counterpart's success, with a two-goal deficit to overturn. With that in mind, Sports Mole has reviewed Liverpool's brace of triumphs.
Barcelona 0-1 Liverpool, 1976
A lot of the talk prior to the first leg of this UEFA Cup semi-final centred around Johan Cruyff and how the 1974 Ballon d'Or winner would cause damage to the Merseysiders. As it would prove, though, the Dutch international was outshone by Liverpool's Kevin Keegan.
The number seven was a real thorn in the side of the home team's defence, which culminated in him setting up the only goal of the game in the 13th minute when he chested the ball into the path of John Toshack, who fired in from close range.
As the final whistle was blown, the home fans littered the pitch with cushions in protest at the performance that their team had produced. Speaking afterwards, Liverpool manager Bob Paisley said: "Every cushion on the pitch was a tribute to our play."
Barcelona 1-2 Liverpool, 2007
Liverpool's build-up to the first leg of this last-16 Champions League tie was dominated by a fracas at a training camp between Craig Bellamy and John Arne Riise, during which it was claimed that the former had struck the latter with a golf club.
The Welsh striker went on to admit the incident in his autobiography Goodfella, saying: "I just whacked him across the backside with the club. You couldn't really call it a swing. It was just a thwack really. Ginge panicked. He curled up in a ball with a blanket."
Nevertheless, both players were included in the starting lineup by manager Rafael Benitez against Barca - a decision that would end up being a masterstroke.
Deco headed the home team in front early on, but Bellamy responded just two minutes before the break when his header was allowed to cross the line by Victor Valdes. His celebration was just as memorable as his goal as he run to the corner flag, before displaying a golf swing.
Then, in the closing stages, Bellamy turned provider for none other than Riise, who fired the ball into the roof of the Barca net from 12 yards out to secure a surprise win at the expense of the holders.
Speaking after the match, Benitez said: "I am really pleased for Bellamy and Riise. The atmosphere in the team is very good. The training camp in Portugal was helpful. The players' commitment was good before and after the problems."
The Spaniards won the return meeting at Anfield 1-0 courtesy of a strike from former Chelsea frontman Eidur Gudjohnsen, but it was Liverpool that advanced through to the last eight of the competition on the away goals rule.