The Reds are expected to make do without Thiago Alcantara until after the next international break, while Harvey Elliott is now on the long road to recovery following ankle surgery, but Naby Keita is now back in training.
The Reds should certainly shuffle the pack in defence with Joe Gomez and Ibrahima Konate both waiting in the wings, and Virgil van Dijk may be protected for the weekend's clash with Manchester City as Konate partners Joel Matip.
Fabinho and Jordan Henderson - the match-winner against AC Milan on the opening day - seem set to reprise their roles in midfield, while Curtis Jones could fend off competition from James Milner and Alex Oxlade-Chamberlain for the final spot in the triumvirate.
Klopp will still rely on some of his big-hitters against an outfit as defensively resilient as Porto, with Mohamed Salah - who bagged his 100th Premier League goal for the club at the weekend - likely to continue on the right.
Liverpool possible starting lineup: Alisson; Gomez, Matip, Konate, Tsimikas; Henderson, Fabinho, Jones; Salah, Firmino, Minamino body check tags ::