The Reds saw Thiago Alcantara pull up with a calf problem in Saturday's Premier League win over Crystal Palace, and the former Bayern Munich man is being kept company in the treatment room by Harvey Elliott and Roberto Firmino.
Alisson Becker is set to hand the gloves over to Caoimhin Kelleher for one evening, while Nat Phillips, Joel Matip and Andy Robertson - the latter two of whom were rested at the weekend - could return to the backline.
Naby Keita put the cherry on the icing on the cake with Liverpool's third against Palace and should now earn a start in midfield alongside Curtis Jones, while workhorse James Milner - who featured at right-back on Saturday - may complete the engine room.
With Mohamed Salah and Sadio Mane expected to be kept in reserve or granted complete rests, Alex Oxlade-Chamberlain is a potential starter out wide, although Klopp also has 16-year-old Kaide Gordon vying for a first-team chance on the right wing.
Takumi Minamino is a sure-fire starter on the opposite side as Divock Origi leads the line, with the Belgian striker overcoming cramp in time to make a late substitute appearance in the win over Palace.
Liverpool possible starting lineup: Kelleher; Gomez, Phillips, Matip, Robertson; Milner, Keita, Jones; Oxlade-Chamberlain, Origi, Minamino body check tags ::