The Hatters have lost their last two league fixtures and sit nine points adrift of safety, while the Owls are still just six points below the playoffs.
With six defeats from their last seven Championship fixtures no team in the league is enduring as poor a run of form as Graeme Jones's side.
Luton also have the worst home record in the second tier and have taken just 18 points from their 15 matches at Kenilworth Road.
Having taken just two points from their last four Championship fixtures, Garry Monk's side have slipped down the table but remain in contention for promotion.
With a clean sheet against Luton in their last three meetings and the eighth best away record in the division, Sheffield Wednesday look to be favourites for this match on paper.
However, Monk's side have scored just four goals in their last six league fixtures and with Steven Fletcher still out injured, they need to find more goals as soon as possible.
The arrival of Connor Wickham should help in that regard, while over the course of the season no team has scored more goals away from home.
Luton Town Championship form: LLLWLL
Luton Town form (all competitions): LLLWLL
Sheffield Wednesday Championship form: LWLLDD
Sheffield Wednesday form (all competitions): WLWLDD
Sheffield Wednesday's top scorer Fletcher is still an absentee and is not expected to return to the squad until March, with loanee Wickham set to make just his second appearance for the club.
Luton Town possible starting lineup:
Sluga; Bree, Pearson, Carter-Vickers, Potts; Moncur, Mpanzu, Tunnicliffe; LuaLua, Collins, Brown
Sheffield Wednesday possible starting lineup:
Dawson; Iorfa, Lees, Borner, Palmer; Lee, Bannan, Windass; Cruz, Wickham, Murphy
We say: Luton Town 0-2 Sheffield Wednesday
Sheffield Wednesday may have been struggling for form of late but they should still have enough to overcome a Luton side in freefall. With the Owls still in contention for a playoff push, expect their quality to show at Kenilworth Road.
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