Interim manager Ralf Rangnick is expected to make wholesale changes to his XI, with the Red Devils already booking their spot in the last-16 stage of the competition as winners of Group F.
Van de Beek has struggled for starts for much of the season, while Henderson has also played once at club level this term due to David de Gea's form between the sticks.
However, Rangnick has confirmed that both players will be given opportunities to impress against Young Boys at Old Trafford.
"To start with, they will both play in the first XI tomorrow. And, as you saw, Donny came on as a sub last Sunday," Rangnick told reporters.
"I know that Dean is a very, very good, ambitious goalkeeper but we definitely need two goalkeepers. We have even three with Tom [Heaton] and with [Lee] Grant we have a fourth one. So we have four goalkeepers but we have the three goalkeepers that come into recognition for the first-team.
"I have to get to know the players first in the next couple of weeks in order to finally assess them. Right now, I am more than happy to have them all on board and I will try to give them as much game-time as possible."
Man United are next in Premier League action away to basement side Norwich City on Saturday afternoon.