Following the unexpected postponement of their league clash with rivals Liverpool at the weekend, the Reds are expected to have an almost full-strength squad to choose from - with only Anthony Martial and Phil Jones still unavailable for selection through injury.
Martial injured his knee on international duty and was not expected to return to action before the end of the season, but he was recently pictured walking without a leg brace and may yet feature ahead of the final - should United get there. Meanwhile, Jones remains out due to a long-term knee injury which has blighted his 2020-21 campaign.
Should he deem it necessary to field his first choice European XI - even with a four-goal advantage in hand - Ole Gunnar Solskjaer's side is most likely to feature Fred and Scott McTominay as its central-midfield pairing, otherwise Nemanja could be given the nod.
Both Paul Pogba and Edinson Cavani - left out of the lineup last time out in the Premier League, versus Leeds United - hope to start in Rome, while Mason Greenwood is poised to stake a claim for a starting spot.
Marcus Rashford should again start in support of Cavani or Greenwood, with Pogba most likely featuring in the more prominent attacking role that has suited him so well of late.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Bailly, Maguire, Telles; Matic, Fred; Rashford, Fernandes, Pogba; Greenwood
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