Bruno Fernandes fired Manchester United into the FA Cup fifth round after coming off the bench to dump Liverpool out of the competition.
The Portugal international struck with a stunning 78th-minute free-kick to make it 3-2 and settle a thrilling fourth-round encounter at Old Trafford.
Mohamed Salah had put the Premier League champions ahead with a deft 18th-minute finish and after Mason Greenwood and Marcus Rashford had turned the tie around, Salah levelled it at 2-2 in the 59th minute.
However, Fernandes ensured it was Ole Gunnar Solskjaer's men who progressed to host top-flight rivals West Ham in the next round when he smashed a dipping free-kick across keeper Alisson Becker and inside the far post.
Tammy Abraham eased the pressure on Chelsea boss Frank Lampard with a hat-trick in a 3-1 home win over Championship Luton.
The England forward scored twice before the break and after Jordan Clark had reduced the deficit, added a third 16 minutes from time to take his tally for the season to 11.
Timo Werner passed up an opportunity to increase the margin of victory when he had a late penalty saved by Hatters keeper Simon Sluga, but a fifth-round trip to Barnsley had already been booked.
Dominic Calvert-Lewin set the ball rolling as Everton also eased their way past Championship opposition to set up a clash with either Wycombe or Tottenham.
The England international gave his side a 29th-minute lead over Sheffield Wednesday at Goodison Park, and further goals from Richarlison and Yerry Mina inside three second-half minutes completed a 3-0 win.
Jay Rodriguez led the way for Burnley with a double in an impressive 3-0 victory at Fulham.
The striker opened the scoring in the 31st minute and then converted a 71st-minute penalty before defender Kevin Long cemented a win which ensured a home tie against either Bournemouth or Crawley.
Leicester had to come from behind to see off cup specialists Brentford 3-1 at the Brentford Community Stadium.
Defender Mads Bech Sorensen gave the Bees, who reached the semi-finals of the Carabao Cup, an early lead, but second-half goals from Cengiz Under, Youri Tielemans and James Maddison denied them another top-flight scalp and handed the much-changed Foxes a home clash with Brighton.