A moment of magic deep into stoppage time from Robin van Persie rescued a 2-2 draw and this replay for Manchester United from their trip to West Ham United just over a week ago.
Two headed goals from James Collins had put the Hammers in front but substitute Van Persie intervened with virtually the last kick of the game.
The Dutch striker isn't expected to start for hosting United on Wednesday though, with the Red Devils likely to hand a starting role to Mexican international Javier Hernandez.
Meanwhile, Wayne Rooney and Portuguese winger Nani have also been tipped to return from injuries during the encounter.
Other squad players could also come into the home team's starting lineup, including Phil Jones, Chris Smalling, Alexander Buttner and Paul Scholes.
Visiting manager Sam Allardyce may make a handful of changes, with Marouane Chamakh likely to make his full debut following his loan move from Arsenal earlier this month.
The last time these two teams met in the FA Cup at Old Trafford, Man United ran out 6-0 winners in 2003.
Recent form
Man United: WDWWWW
West Ham: LDLLWL
Possible starting lineups:
Man United: Lindegaard; Buttner, Smalling, Jones, Rafael; Valencia, Scholes, Anderson, Nani; Rooney, Hernandez
West Ham: Jaaskelainen; Reid, Demel, Potts, Collins; Diarra, Collison, Nolan, Jarvis; J Cole; Chamakh
Sports Mole says: 3-1
