The Portugal international started on the bench for his side's last fixture against Everton but is expected to return to the starting XI at the King Power Stadium.
Ronaldo has only faced Leicester on one previous occasion - a 1-0 victory during the 2003-04 Premier League season, with Gary Neville scoring the winner at Old Trafford.
The 36-year-old has netted against 119 different opponents in his club career and will be attempting to take that number to 120 when he faces Brendan Rodgers's side.
Ronaldo has been in impressive form for Ole Gunnar Solskjaer's team since returning over the summer, scoring five times in six appearances in all competitions.
The Portuguese also netted four times in two appearances for his country over the recent international break, including a treble against Luxembourg in a World Cup qualification fixture. body check tags ::