The Red Devils, who currently sit fourth in the Premier League table, travel to the Foxes who are 13th.
Ole Gunnar Solskjaer's side have suffered back-to-back defeats against the East Midlands outfit - losing 3-1 in the FA Cup quarter-finals last season and then 2-1 in the league a little under two months later.
However, Man United have not lost three consecutive games against Leicester since November 1901, a feat that Solskjaer will hope remains consigned to history.
The Red Devils have lost three of their last six matches in all competitions and headed into the international break with a 1-1 draw against Everton.
The Foxes are still yet to find their feet this season and have won only one of their last six games in all competitions, but will have taken the opportunity to reset over the last fortnight. body check tags ::