The hosts are one of only four teams in the division to have claimed just four home victory so far this campaign, and face a Boro outfit who have won two of their last three away matches.
Millwall were unable to build on last weekend's win over Derby County as they let a two-goal lead slip against Queens Park Rangers, losing 3-2 away at Loftus Road on Wednesday night.
Jed Wallace and Mason Bennett gave the Lions a first-half lead, however the hosts fought back after the break, with a late header from Jordy de Wijs turning the game on its head to snatch all three points from their London rivals.
Millwall remain in 10th place, but their hopes of securing a playoff spot are now slipping away, with an 11-point gap separating them from the top six.
The Lions head into Saturday's clash with a poor record against Middlesbrough in recent seasons, after failing to win any of their last six league meetings against them.
Millwall are looking to avoid losing consecutive home league games for the first time since March 2019 under former head coach Neil Harris.
Middlesbrough secured their third league win in four matches as they eased past 10-man Preston North End with a 2-0 home victory on Tuesday night.
That result keeps Boro in the race for a playoff place and they are just five points behind sixth-placed Reading, with nine Championship matches left to play.
Warnock's side now face four consecutive league games against teams currently in the top 10, with Saturday's trip to Millwall followed by fixtures against Barnsley, Bournemouth and Watford.
Middlesbrough convincingly beat Millwall earlier this season, winning 3-0 on home soil, and another victory against them this weekend would see Boro complete their first league double over the Lions since the 2014-15 campaign under former boss Aitor Karanka.
Millwall's George Evans has featured eight times as a defender since joining the club in January, but has started the last two matches in midfield and could keep his place there this weekend alongside Ryan Woods and Ben Thompson.
Jon Dadi Bodvarsson will be hoping to force his way back into the first XI after starting the last two matches on the bench.
Millwall possible starting lineup:
Bialkowski; Hutchinson, Pearce, Cooper; Romeo, Evans, Thompson, Woods, Malone; Wallace, Bennett
Middlesbrough possible starting lineup:
Bettinelli; Fisher, Fry, Hall, Bola; McNair, Morsy, Howson; Bolasie, Akpom, Kebano
We say: Millwall 1-2 Middlesbrough
Millwall have drawn 16 Championship matches this season – twice as many as Middlesbrough – with 10 of those at The Den, and the Lions will be hoping to claim all three points against the visitors to end their poor run of form on home soil.
However, Warnock is keen to ensure that his side stay in the hunt for a playoff spot, and having scored in each of their last 16 meetings with Millwall, we expect Boro to find the net once again on Saturday and claim a narrow victory.
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