The visitors have won one of their last four matches and are only two places above the dotted line, while back-to-back draws for Napoli leaves them in sixth.
Udinese may have a seven-point margin on the relegation zone, but the bottom four all face off this weekend and that gap could reduce should they taste defeat in Naples.
The Bianconeri held out-of-form Lazio to a goalless draw on home soil on Wednesday evening to put last week's 3-1 loss at the hands of Sampdoria behind them.
Luca Gotti's side have saved their best results for the road since last month's restart, having beaten Roma and bottom side SPAL in their last two away games.
Not since May 2013, when Francesco Guidolin was at the helm, have Udinese won three away games in a row in Serie A.
Napoli are unbeaten in their last seven games at home in all competitions, though, most recently playing out an entertaining 2-2 draw with AC Milan.
Milan have closed the gap on sixth-placed Napoli and are now level on points with them, though Gennaro Gattuso's side are already assured of a European spot by virtue of winning the Coppa Italia.
Indeed, that domestic cup success last month ensures that this will go down as a season to remember for Napoli regardless of what happens in their remaining league games.
Gattuso's side will already have one eye on August's rearranged Champions League last-16 second leg against Barcelona, with that one finely poised at 1-1 following the first leg.
Napoli will be eager to regain some momentum before then, and this fixture presents them with a chance to return to winning ways.
The Partenopei have won seven and drawn one of their last eight meetings with Udinese on home soil in a run stretching back to April 2011.
Napoli's Serie A form: WLWWDD
Udinese's Serie A form: LWDWLD
Mertens has been directly involved six goals in his last three games against Udinese, scoring two and setting up four more.
After failing to score in his first four Serie A appearances against Napoli, Lasagna scored in both games played against the Partenopei in 2019.
Napoli possible starting lineup:
Meret; Hysaj, Manolas, Koulibaly, Rui; Ruiz, Demme, Zielinski; Politano, Mertens, Insigne
Udinese possible starting lineup:
Musso; Becao, Maio, Nuytinck; Larsen, De Paul, Walace, Fofana, Sema; Teodorczyk, Lasagna
We say: Napoli 2-0 Udinese
Udinese have won back-to-back away matches but are without a victory in this fixture home or away in more than four years. Napoli have scored at least two goals in their last six home games in Serie A - their best run since 2014 - and we can see them getting back on the winning trail this weekend.