Meanwhile, the away side are aiming to stretch their six-game unbeaten streak further and maintain their lead over the hosts on the log.
New York City FC followed up a narrow 1-0 win over CF Montreal on Thursday with a more comprehensive 5-0 demolition of Orlando City SC on Sunday.
After a relatively quiet first half where Jesus Medina's opener proved to be the only moment of note, the game sprung into life in the second 45 minutes as goals from Ismael Tajouri-Shradi, Maxi Moralez, Malte Amundsen and Valentin Castellanos secured a convincing win for Ronny Deila's men.
With 23 points from a possible 42, the Pigeons have moved up into sixth place on the Eastern Conference standings and are just two points off second-placed Nashville SC.
Their goal fest last time out means that only league leaders New England Revolution and Kansas City have found the back of the net on more occasions than the Bronx-based club.
Saturday's hosts seek to turn a corner, as they have struggled in games against their visitors of late, losing each of the last three meetings by a combined of 7-3.
Columbus Crew saw off the threat of Atlanta United courtesy of a 1-0 win when the sides faced off at the Mercedes-Benz Stadium on Saturday.
Despite possessing the best defensive record in the East, the Crew are only in fifth position, majorly due to their inadequacies at the other end.
Saturday's visitors have scored just 16 goals in 15 games to date, a tally which is currently surpassed by all but two teams in the division.
Brazilian forward Heber continues his spell on the treatment table after picking up a knee injury which has ruled him out of action for the past ten months.
Milton Valenzuela is ruled out with a thigh injury, while 19-year-old Aidan Morris remains sidelined with a knee injury.
Josh Williams has missed eight of his side's 15 league outings this term, but the American defender could make his return to action in the coming weeks.
New York City FC possible starting lineup:
Barraza; Tinnerholm, Channot, Callens, Thorarinsson; Morales, Acevedo, Medina; Moralez, Tajouri, Castellanos
Columbus Crew possible starting lineup:
Room; Santos, Mensah, Keita, Abdul-Salaam; Molino, Nagbe, Hairston, Matan; Hurtado, Wright-Phillips
We say: New York City FC 2-0 Columbus Crew
The visitors have struggled on the offensive end away from home all-season long, and we can see that trend continuing here. We are backing the hosts to grab all three points while also keeping a clean sheet en route.
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