Millwall are without a league win in their previous three outings but are a hard team to defeat, having suffered just one loss in their last five games in all competitions.
A narrow victory over Cardiff City on Saturday ensured Forest progressed to the FA Cup fourth round and made it back-to-back 1-0 victories for the City Ground outfit.
Hughton's men may have struggled for goals this season, but the former Newcastle United and Brighton & Hove Albion manager has managed to shore up his side's defence in recent weeks.
After a run of three consecutive defeats at the start of December, which saw them concede seven goals, they have only let in two in their following six encounters.
Millwall have drawn the most games in the second tier so far this season, having taken home a share of the spoils on 11 occasions in 2020-21, which is half of their matches to date.
Their stubborn, if unattractive nature, currently sees them sitting in 16th position in the table, seven points clear of the relegation zone and four points better off than their upcoming opponents.
The Lions finished an impressive eighth in the previous campaign, narrowly missing out on a place in the playoffs, but this season has been a struggle at times.
Millwall's games are often tight affairs containing few goals, and that is exactly how it panned out between the two teams just a month ago.
They played out a closely fought 1-1 drw at The Den in the build-up to Christmas, and it could be a similar occasion at the weekend.
Nottingham Forest Championship form: LWDDDW
Nottingham Forest form (all competitions): WDDDWW
Millwall Championship form: DLWDLD
Millwall form (all competitions): LLDLWD
Midfielder Luke Freeman is expected to return to the Forest bench after a lengthy lay-off meaning Hughton has a fully-fit squad to choose from.
Star striker Kenneth Zohore made his first league start in several weeks following an injury last time out, but his replacement Matt Smith grabbed a late equaliser and could be pushing for a start at the weekend.
Nottingham Forest possible starting lineup:
Samba; Ribeiro, Worrall, Figueiredo, Christie; Sow, Yates; Ameobi, Cafu, Knockaert; Grabban
Millwall possible starting lineup:
Bialkowski; Cooper, Pearce, Hutchinson; Wallace, Woods, Leonard, McNamara; Parrot, Smith, Wallace
We say: Nottingham Forest 1-0 Millwall
It is likely to be a hard-fought fixture with few chances at either end, given the two team's strengths lie in defence. A narrow victory for Forest could be the outcome on Saturday as the home side carry greater momentum into the game.