Meanwhile, Nacional have lost their last three games in Portugal's top flight, leaving them just three points ahead of the relegation zone.
With Porto and Benfica having struggled for wins of late, Pacos de Ferreira may never have a better opportunity to finish ahead of the two Portuguese giants in Primeira Liga.
However, Pepa's immediate concern is ensuring that his side do not drop out of the top five after collecting just four points from as many matches.
The latest setback, a 3-0 reverse at Santa Clara, represented a major blow to Os Castores, who now only sit three points above Vitoria de Guimaraes.
While a home meeting versus Nacional gives Pacos de Ferreira every chance of getting back on track, Pepa will have concerns with how his team have handled losing their recent six-match winning streak.
On the plus side, you have to go back to September 27 for the club's last home defeat, a period stretching stretching nine matches.
Nacional's campaign has been a tale of inconsistency with unbeaten runs and losing streaks occurring in equal measure.
As it stands, Luis Freire has witnessed his side lose successive games to Farense, Belenenses and Braga, a run which has followed eight points being collected from four matches.
Now sitting down in 12th position and just three points off bottom place, everyone associated with Alvinegros will be frustrated with their current situation.
However, they have scored in all but three of their last 13 matches, a return which will only encourage Freire ahead of the trip to Estadio da Mata Real.
Pacos de Ferreira Primeira Liga form: WWDLWL
Nacional Primeira Liga form: WDWLLL
Pepa is likely to make numerous alterations to his Pacos de Ferreira side, including handing a recall to left-back Pedro Rebocho.
Nacional goallkeeper Riccardo Piscitelli should keep his place between the sticks despite his poor performance against Braga.
Pacos de Ferreira possible starting lineup:
Jordi; Fonseca, Marcelo, Maracas, Rebocho; Carlos, Eustaquio, Costa; Ferreira, Tanque, Santos
Nacional possible starting lineup:
Piscitelli; Kalindi, Pedrao, Correia, Vigario; Ramos, Borges, Micael; Thill, Riascos, Gorre
We say: Pacos de Ferreira 2-1 Nacional
With European qualification in their sights, Pacos de Ferreira have struggled to handle the pressure in recent weeks. However, we are backing the home side to edge their way to victory on Friday, potentially by the odd goal in three against out-of-form opponents.