Unbeaten in their last 11 matches across all competitions, high-flying PSV Eindhoven welcome Fortuna Sittard to the Philips Stadion on Sunday.
The home side are also looking to complete a league double over this weekend's opponents off the back of a 2-0 victory in November's reverse fixture.
Match preview
PSV breezed past FC Copenhagen in the last 16 of the Conference League following a 4-0 second-leg victory at the Parken Stadium on Thursday.
Eran Zahavi was at the double in the Danish capital with Mario Gotze and Noni Madueke also getting on the scoresheet for Roger Schmidt's men.
Prior to that, the Rood-witten saw off the threat of FC Utrecht on Sunday to remain within two points of Ajax at the top of the Eredivisie table.
Their next assignment sees them go up against an opposing side who have lost each of the last nine meetings between the teams dating back to 2001.
With only little margin for error in the title race, Sunday's hosts have to be near-perfect from here on out if they are to be crowned champions come May.
Fortuna snapped a two-game losing streak by narrowly beating Willem II 1-0 when the sides faced off in a crunch relegation six-pointer on Sunday.
Zian Flemming was the hero for Sjors Ultee's men in Sittard as his 53rd-minute opener proved to be enough to secure all three points.
Consequently, The Fortunezen have moved out of the bottom three, albeit only on goal difference, but they still have a game in hand on majority of the teams in and around them.
Having conceded a league-high 29 goals on the road, Sunday's visitors will need to be wary of being picked apart against a PSV side who have scored the second-most goals on home turf.
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Team News
PSV's Cody Gakpo was forced off with an injury in midweek, and the winger is expected to be unavailable for Sunday's game as a result.
Mees Kreekels, Ryan Thomas and Shurandy Sambo remain sidelined with knee injuries, while Andre Ramalho continues to nurse an ankle problem.
Ritsu Doan was on fire in the reverse fixture, where he found the back of the net twice, and the forward will be looking to deliver the goods once again.
Arianit Ferati has missed each of Fortuna's last four matches due to a muscle problem which is set to keep the 24-year-old out yet again.
The away side will also be without the services of Ryan Johansson, but the Irishman could make his return to action in the coming weeks.
PSV Eindhoven possible starting lineup:
Drommel; Max, Obispo, Teze, Mauro; Sangare, Gutierrez, Gotze; Doan, Zahavi, Veerman
Fortuna Sittard possible starting lineup:
Van Osch; Tirpan, Angha, Siovas, Cox; Semedo, Duarte, Rienstra; Flemming, Seuntjens, Benschop
We say: PSV Eindhoven 3-0 Fortuna Sittard
Buoyed by their huge victory last time out, PSV will head into this one full of confidence, and we are backing them to come away with all three points in emphatic fashion.
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