Los Blancos recorded a 2-0 victory the the two teams last met back in March, but the capital giants - currently third in Spain's top flight - will enter this match off the back of successive defeats.
Here, Sports Mole looks at how Madrid could line up this weekend.
Madrid will again be without the services of Eden Hazard, Dani Carvajal and Martin Odegaard this weekend, while Mariano Diaz and Alvaro Odriozola are also unlikely to be available for selection.
Club captain Sergio Ramos was forced off at the interval of the defeat to Cadiz and was not involved against Shakhtar in the Champions League on Wednesday night, but the Spaniard is expected to be back in the XI on Saturday afternoon despite being forced to train away from his teammates on Thursday.
Karim Benzema and Vinicius Junior should also both return to the XI in place of Rodrygo Goes and Luka Jovic, but Marco Asensio could keep his spot on the right ahead of the likes of Isco and Lucas Vazquez.
> Click here to see how Barcelona could line up for the contest body check tags ::