Real Madrid are facing being without as many as nine first-team players for their next match, which comes against Cadiz immediately after the international break.
Los Blancos recorded a 5-1 win over Valencia in La Liga last weekend, which left them in second position in the table, two points behind leaders Girona.
Carlo Ancelotti's side are also through to the knockout round of the Champions League with two games to spare, having beaten Braga 3-0 on November 8.
Real Madrid will be back in action away to Cadiz on November 26, before ending the month with a home game against Napoli in the Champions League.
Eder Militao and Thibaut Courtois remain long-term absentees with serious knee injuries which were suffered earlier this season, with neither player given a firm return date at this stage.
Aurelien Tchouameni is also out, potentially until the end of the year, with a broken foot that he suffered in El Clasico, while Arda Guler has had another injury setback, picking up a fresh muscular issue which will likely keep him out until the start of December.
Kepa Arrizabalaga suffered a muscular problem in the warm-up ahead of the recent Champions League game with Braga, and he is also absent until December.
Real Madrid have also been hit with two injury blows during the international break, with Eduardo Camavinga picking up a knee ligament injury during a training session with France.
Camavinga is facing up to two months on the sidelines, while Vinicius Junior suffered a thigh problem during Brazil's contest with Colombia on Thursday night, which might keep him out for a month.
Dani Ceballos is back in training following a muscular issue, but it remains to be seen whether the midfielder is cleared to make the squad against Cadiz.
Real Madrid are also sweating over the fitness of Jude Bellingham, who did not feature against Valencia last time out due to a shoulder problem that he picked up against Rayo Vallecano on November 5.
Bellingham, who has been named the Golden Boy for 2023, was forced to pull out of the England squad with the issue, and he faces a battle to be available for the game with Cadiz.
As a result, Real Madrid face being without the services of nine important players, and the injuries are a concern considering that the team will play another seven games before the end of the year.
The team, as mentioned, are through to the knockout round of the Champions League, but Girona are setting the pace at the top of the La Liga table, meaning that any slip-ups at this stage could be very costly.