Villarreal vs. Rayo Vallecano (Sunday, 1.00pm)
After advancing into the knockout stage of the Champions League earlier this week, Villarreal can end a three-game winless run in La Liga when they host Rayo Vallecano on Sunday from Estadio de la Ceramica.
The Europa League winners from a season ago sit 14th in the standings, four points ahead of the relegation zone, while the club from Vallecas have been one of the surprise stories in Spain domestically, currently in sixth with 27 points, unbeaten in their last four matches in all competitions.
We say: Villarreal 2-2 Rayo Vallecano
El Submarino Amarillo have only won one of their last five matches versus Vallecano, but they do not have any problems finding the back of the net against the Segunda Division winners from last season, averaging 2.8 goals per game in their previous six home fixtures against them in La Liga.
Los Vallecanos have a lot of momentum and a desire to be right up there with the top teams in Spain, and even though they have struggled away from home, they have plenty of quality to put a couple past Villarreal, who are not feeling great about their form domestically at the moment.
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Osasuna vs. Barcelona (Sunday, 3.15pm)
Barcelona will be looking to bounce back from successive defeats when they continue their La Liga campaign away to Osasuna on Sunday afternoon.
Xavi's side are currently seventh in Spain's top flight, 16 points behind the leaders Real Madrid, albeit with a game in hand, while Osasuna are 10th in the division, collecting 21 points from their first 16 games.
We say: Osasuna 1-2 Barcelona
It is difficult to back Barcelona to win at the moment, especially away from home, but we believe that there will be a reaction from their Champions League exit. Osasuna are more than capable of picking up a positive result here, though, and it is likely to be a very tight match on Sunday afternoon.
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> How Barcelona could line up against Osasuna
> Barcelona injury, suspension list vs. Osasuna
Real Betis vs. Real Sociedad (Sunday, 5.30pm)
Fresh off the back of securing their place in the knockout stages of the Europa League, Real Sociedad travel to the Benito Villamarin Stadium to face Real Betis on Sunday.
The hosts, who also progressed to the next round of the Europa League, will be seeking to build on their impressive victory over Barcelona and continue their winning streak in the league.
We say: Real Betis X-Y Real Sociedad
Both sides find themselves in the upper echelons of the La Liga standings after an impressive start to the season. Real Betis, who have won their last three league games on the spin, head into the game as the more in-form side and we are tipping them to come away with all three points, albeit by a narrow margin.
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Real Madrid vs. Atletico (Sunday, 8.00pm)
One of the biggest fixtures on the European calendar will take place at Bernabeu on Sunday night, as Real Madrid welcome bitter rivals Atletico Madrid for the Madrid derby.
A brilliant 2021-22 campaign to date has left Los Blancos top of La Liga with 39 points to show from their opening 16 matches, while Atletico are fourth, 10 points behind their opponents here.
We say: Real Madrid 1-1 Atletico Madrid
Real Madrid will be confident of putting a 10th straight victory on the board this weekend, and we were initially leaning towards a home success here. Atletico tend to pick up results when they need it the most, though, and we just have a feeling that Simeone's side will do enough to secure a share of the spoils.
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> How Real Madrid could line up against Atletico Madrid
