Gonzalo Bergessio and Eder have been chosen to lead the line for Sampdoria in their Serie A match against Empoli this afternoon.
Argentina international Bergessio comes in for Stefano Okaka, following Monday evening's 3-0 defeat against Lazio.
There are three other changes for the hosts, as Lorenzo De Silvestri, Matias Silvestre and Alfred Duncan all return to the starting lineup.
Meanwhile, Empoli have made a couple of changes to their side, as Federico Barba comes in for the suspended Lorenzo Tonelli and Manuel Pucciarelli replaces Francesco Tavano up front.
Sampdoria: Viviano; De Silvestri, Gastaldello, Silvestre, Regini; Obiang, Palombo, Duncan; Soriano; Eder, Bergessio
Empoli: Sepe; Hysaj, Rugani, Barba, Mario Rui; Croce, Valdifiori, Vecino; Verdi; Maccarone, Pucciarelli