Kevin-Prince Boateng has not been included in Jens Keller's squad for their trip to Nuremberg in the Bundesliga due to an injury picked up in training.
It means that Adam Szalai leads the line for the away side, ahead of an attacking trio of Christian Fuchs, Jefferson Farfan and Max Meyer.
For the hosts, who have slipped to bottom after Eintracht Braunschweig's win, Daniel Ginczek is named as the lone striker with Hiroshi Kiyotake floating behind.
Nuremberg: Schafer; Chandler, Nilsson, Pinola, Plattenhardt; Frantz, Hasebe; Drmic, Kiyotake, Hlousek; Ginczek
Schalke: Fahrmann; Uchida, Matip, Santana, Kolasinac; Jones, Neustadter; Farfan, Meyer, Fuchs; Szalai