However, they face a Tangerines side still seeking their first win of the season and facing the possibility of a back-to-back relegations.
Scunthorpe boss Mark Robins is hoping to avoid a fight for survival for the second successive season as the Yorkshire club play out their final campaign at Glanford Park.
The Iron are set to move to a new purpose-built ground in the Lincolnshire Lakes area of the town, but United are in danger of playing their first game there in League Two.
Scunthorpe's season got off to the worst possible start as they lost at Burton Albion before being beaten on penalties by Barnsley in the League Cup.
Successive draws against Millwall and Colchester United have left the Iron just above the drop zone, but a rare victory for Scunny could see them into the top 12.
However, stretching back to the final day of the season, the Yorkshiremen have now won only once in their last eight games in all competitions.
Recent form: LLWLDD
Recent form (all competitions): DWLDDL
Blackpool are facing the prospect of potentially dropping into League Two, only five years after facing Manchester United in the Premier League.
The Tangerines have struggled for form since the start of the season when they battled to a draw at Colchester United.
However, defeat at Northampton Town in the League Cup, where Neil McDonald's side conceded three before half time, started a miserable run.
They lost to Rochdale and Burton Albion at home before another defeat away to Sheffield United, but arguably their worst result came last weekend against Walsall.
Blackpool's 4-0 defeat to the Saddlers left the Tangerines with only one point to their name and without an away victory since beating Huddersfield Town in March 2014.
Their home form is little better, with only four wins in that time, but McDonald has dipped into the transfer market to bolster his squad with midfielder David Norris following his release by Yeovil Town.
Recent form: LDLLLL
Recent form (all competitions): DLLLLL
Scunthorpe may look to make changes to their starting lineup after their Johnstone's Paint Trophy defeat at home to Barnsley in midweek.
Luke Daniels could keep his place in goal after serving a suspension, following his red card against Burton Albion at the start of the season.
Meanwhile, Blackpool may look to reshuffle their team after their humbling defeat to Walsall, although McDonald may decide not to rush back keeper Colin Doyle after a lengthy layoff.
Cubero was due to be on international duty with Costa Rica, but is now available for the Fylde club.
Scunthorpe United possible starting lineup:
Anyon, Clarke, Goode, King, Wallace, Laird, McAllister, Bishop, Van Veen, Henderson, Madden
Blackpool possible starting lineup:
Letheren, Boyce, Aldred, Robertson, Ferguson, Cameron, Cubero, McAlister, Rivers, Thomas, Cullen
Head To Head
One crumb of comfort for travelling Tangerines fans will be their recent record against Scunny, having won eight and lost only one of their last 10 encounters with the Iron.
That solitary defeat came back in April 2006 when a 90th-minute Billy Sharp goal gave United the spoils.
Blackpool's last visit to Glanford Park saw DJ Campbell score twice as the Seasiders won 4-2 on their way to Premier League promotion in 2010.
We say: Scunthorpe 1-0 Blackpool
Scunthorpe's indifferent home form may present Blackpool with a great chance to pick up only their fifth league victory since March 2014, but one point from the Tangerines' first five games suggests that United could edge this encounter.