With five wins in their last six league games, Sevilla are the most in-form side in the division and could leapfrog Real Madrid and Barcelona into second place with a win on Wednesday evening.
Following a medley of both good and bad performances, hosts Levante are starting to look like La Liga's most unpredictable outfit.
In the last few weeks alone they have beaten Valencia and Eibar and also lost to the likes of Huesca, Real Betis and, most recently, Villarreal.
If Levante are to take anything away from this tie, a lot may rest on the shoulders of striker Roger Marti, who has 11 goals so far this season.
After overcoming a blip in form in late February, Lopetegui's Sevilla now look to be as cunning and imperious as ever and are quickly gaining ground on the heavyweights of the division.
Las Palanganas have taken some fairly notable scalps in recent weeks too, with league leaders Atletico Madrid, eternal rivals Real Betis and Imanol Alguacil's Real Sociedad all coming away second best from recent league encounters.
Currently fourth in the standings, just six points off Atleti in first place, it is not unthinkable that Sevilla could become late challengers for the league title.
Unlike earlier on in the campaign, the team's reliance on Youssef En-Nesyri has eased somewhat in recent weeks and Sevilla are now looking really dangerous in other compartments too.
Lopez could tinker with his side following the team's drubbing against Villarreal, but it is unclear how the starting 11 could be improved, with the likes of Jose Luis Morales, Roger and Jorge de Frutos all playing in that game.
Sevilla come into this tie with an entirely fit squad and no absentees, meaning Lopetegui may have a different kind of selection headache on Wednesday.
Levante possible starting lineup:
Fernandez; Coke, Postigo, Duarte, Clerc; De Frutos, Bardhi, Malsa, Morales; Roger, Gomez
Sevilla possible starting lineup:
Bono; Navas, Kounde, Carlos, Acuna; Jordan, Fernando, Gomez; Suso, En-Nesyri, Ocampos
We say: Levante 1-3 Sevilla
Sevilla are really the big dogs in the league right now and, with the firepower Lopetegui's men have at their disposal, it does not look like Levante will be able to find a way to best them. We are going with a 3-1 scoreline.
body check tags ::