The Terriers are currently 20th in the table, just two points above the relegation zone, while Wednesday occupy 14th position and are not in danger of dropping into the bottom three.
Wednesday have finished 15th and 12th in their last two Championship seasons, and it does appear that the club are heading for a similar position this time around.
Indeed, a record of 15 wins, 10 draws and 18 defeats from 43 matches has left them in 14th, 10 points clear of the relegation zone with three games left.
The Owls are five points off 12th, though, suggesting that they will finish in and around their current spot, which is perhaps slightly disappointing considering that they made the playoffs in both 2015-16 and 2016-17.
Garry Monk's side will enter Tuesday's game off the back of an impressive 3-0 win over Queens Park Rangers on Saturday, and there is no question that they will be targeting another victory in this match.
Huddersfield, though, will enter the match off the back of a disappointing 2-0 home defeat to Luton Town on Friday, which has left the Terriers very much in the relegation mix.
Stoke City's 2-0 win over Birmingham City on Sunday afternoon was bad news for Danny Cowley's side, who have now dropped into 20th spot in the table, just two points above 22nd-placed Hull City.
Huddersfield are only two points off 17th-placed Stoke, though, which is an indication of just how tight it is when it comes to avoiding relegation to the third tier of English football.
Cowley's team have two tough games against West Bromwich Albion and Millwall to come, meaning that they might need to pick up a win on Tuesday night to ensure that they stay above the bottom three.
The Terriers have only won five of their 21 away league games this season, but Wednesday's home record is among the poorest in the division, making for an interesting game at Hillsborough.
Sheffield Wednesday Championship form: DWLLLW
Huddersfield Championship form: LLWDDL
Wednesday will again be unable to call upon experienced striker Steven Fletcher due to a hamstring problem, but the Owls did not pick up any fresh issues against QPR.
Joey Pelupessy is also pushing for a spot in midfield, but Monk is likely to keep faith with the majority of the side that impressively triumphed at Loftus Road.
As for Huddersfield, Tommy Elphick is still on the sidelines through injury, but Cowley otherwise has a fully-fit squad to choose from, and there are not expected to be many surprises.
Sheffield Wednesday possible starting lineup:
Wildsmith; Irofa, Lees, Borner; Odubajo, Hunt, Bannan, Luongo, Harris; Windass, Murphy
Huddersfield Town possible starting lineup:
Lossl; Chalobah, Stankovic, Schindler, Toffolo; O'Brien, Hogg; Grant, Smith Rowe, Willock; Campbell
We say: Sheffield Wednesday 1-0 Huddersfield Town
Huddersfield are in desperate need of a win, but we are struggling to back the visitors on Tuesday night. Wednesday were excellent against QPR last time out, and we fancy them to put another three points on the board as they look to end the campaign on a positive note.
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