Swansea City striker Michu makes his first start for world champions Spain as they look to take a major step towards qualification against Belarus.
Barcelona keeper Victor Valdes is preferred in goal by coach Vicente del Bosque with midfielder Andres Iniesta left on the bench.
Ignacio Monreal is picked in defence, with Jordi Alba missing out.
Syarhey Vyeramko continues in goal for the visitors while the experienced Timofei Kalackev also starts.
A win tonight will leave La Roja needing just a point from their final game to qualify for the World Cup.
The game does go ahead despite an electrical generator exploding at the Iberostar yesterday.
Spain: Valdes, Arbeloa, Ramos, Pique, Monreal, Xavi, Busquets, Pedro, Fabregas, Michu, Silva
Belarus: Veremko; Martynovich, Verkhovtsov, Bordachev, Filipenko; Dragun, Zhavnerchik, Putilo, Balanovich; Tigorev, Kalachev