Mourinho's men have a chance to push on following Wednesday's late 2-1 Premier League win over Norwich City, with a cup run high on their agenda.
Ahead of the clash at St Mary's Stadium, Sports Mole looks at how Tottenham could line up.
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Out: Harry Kane (hamstring), Moussa Sissoko (knee), Ben Davies (ankle), Harry Winks (ankle)
Doubtful: Danny Rose (back)
Tottenham welcomed goalkeeper Hugo Lloris back from injury for the win over Norwich, but Mourinho was left to bemoan his side's bad luck as Winks hobbled off early in the second half.
That leaves a gap to be plugged in holding midfield, while Rose's likely absence should see youngster Japhet Tanganga given another chance to impress.
Should Tanganga start, versatile wideman Ryan Sessegnon could be used further up the field, though Lucas Moura is favourite to start on the left after scoring a vital goal to rescue a replay against Boro.
Elsewhere, leading goalscorer Kane remains on the sidelines so Son Heung-min - Tottenham's late hero against Norwich - may once again be asked to lead the line.