Rafael van der Vaart has been ruled out of Holland's friendly encounter against England on Wednesday evening.
The Tottenham Hotspur midfielder is suffering with an ankle injury and as a result will play no part at Wembley.
No details have been released as to the extent of the injury, or how long the 29-year-old will be out of action for.
Van der Vaart's Tottenham teammate Kyle Walker withdrew from the England squad earlier today.