The Potters have seen early strong form under Michael O'Neill abandon them in recent weeks, while Cardiff have moved to within three points of the playoff places.
Stoke have struggled in recent weeks after an impressive resurgence under O'Neill and must now regroup as they look to steer themselves away from relegation.
With three losses in their last four, Stoke's defence has begun to leak and with James McClean picking up a serious injury, they have lost a key attacking component too.
The Potters home form has been good of late, with just one defeat in their last six, but with 11 goals conceded in their last four matches the addition of centre-back James Chester from Aston Villa has not yet had the desired impact.
Stoke came out on the wrong side in the reverse fixture following a Leandro Bacuna winner and will be aware that another defeat could see them back in the relegation zone if results elsewhere go against them.
In direct contrast to Stoke, Cardiff have been in excellent form of late and have not tasted defeat in the league since New Year's Day.
Neil Harris's side are now just a win away from climbing back into the playoffs and with three wins in their last five, they will travel to Staffordshire with confidence.
Cardiff's away form had been an Achilles' heel so far this season, but with three wins from their last five on the road, Harris seems to have found a way to pick up victories.
However, such is the close nature of the Championship, a defeat in the Potteries could leave the Bluebirds as low as 11th in the league table.
Stoke City Championship form: WWLWLL
Cardiff City Championship form: DWDWWD
Cardiff City form (all competitions): WDLWWD
None of them started against Wigan Athletic last time out, but could push for recalls if fit after a disappointing draw.
McClean is Stoke's main absence, with the winger out for at least a month because of a knee injury.
Stoke City possible starting lineup:
Butland; Smith, Batth, Chester, Martins-Indi; Clucas, Allen, Powell; Ince, Campbell, Thompson
Cardiff City possible starting lineup:
Smithies; Richards, Morrison, Nelson, Bennett; Vaulks, Pack; Adomah, Tomlin, Murphy; Paterson
We say: Stoke City 2-1 Cardiff City
Stoke have seen their form dip in recent weeks, but they remain a force at the bet365 Stadium under O'Neill. Cardiff have been in good form of late, but Stoke could sneak a valuable win in their fight against relegation.