Borussia Dortmund coach Jurgen Klopp has had to rejig his entire right-hand side with the absences of both regular starters Jakub Blaszczykowski and Lukazs Piszczek.
In their place are Kevin Grosskreutz at right-back and Mario Gotze on the right of a three-man attack that also includes Robert Lewandowski and Marco Reus.
For the hosting Stuttgart, Vedad Ibisevic starts up front with Romanian Alexandru Maxim providing the attacking support from midfield.
Stuttgart: Ulreich; Sakai, Rudiger, Niedermeier, Felipe; Boka, Gentner; Traore, Maxim, Harnik; Ibisevic
Dortmund: Weidenfeller; Subotic, Grosskreutz, Santana, Schmelzer; Gundogan, Bender, Sahin; Gotze, Reus, Lewandowski