Sunderland boss David Moyes has handed home debuts to a number of players in Sunday's Premier League clash against Middlesbrough at the Stadium of Light.
Adnan Januzaj, Paddy McNair, Donald Love and Papy Djilobodji are in line for their first Black Cats home game, while United States Under-20 international Lynden Gooch is to make his first Premier League start.
Aitor Karanka, meanwhile, has left Victor Valdes and Jordan Rhodes out of the Boro squad this afternoon, while Brad Guzan will make his club debut between the sticks.
There are also changes further forward as Adam Forshaw and Cristhian Stuani replace the benched Albert Adomah and the injured Marten de Roon.
Sunderland: Mannone, van Aanholt, Djilobodji, O'Shea, McNair, Love, Rodwell, Gooch, Watmore, Januzaj, Defoe
Subs: Pickford, Khazri, Lens, Pienaar, Asoro, T Robson, J Robson
Middlesbrough: Guzan, Nsue, Barragan, Gibson, Friend, Clayton, Forshaw, Stuani, Ramirez, Downing, Negredo
Subs: Konstantopoulos, Ayala, Baptiste, De Sart, Adomah, Fischer, Nugent
Follow all the action from the Wear-Tees derby with Sports Mole's live match commentary.