Toronto FC have missed the chance to record four consecutive wins for the first time in their six-year history.
The Canadian side were soundly beaten by Houston Dynamo in front of a largely-disappointed crowd of 19,652 at BMO Field.
Calen Carr headed Houston in front in first-half stoppage and Brian Ching completed the win in the 86th minute with a well-struck left-footed effort from seven yards.
Houston are now unbeaten in seven matches.