Decisive victory in the Derby d'Italia last week saw Inter claim a clear advantage over Juventus and stay in touch with league leaders Milan, while their Friulian hosts remain mired in trouble despite a hard-earned point in midweek.
Inter's success in Calcio's biggest game last Sunday was such that even old rival Giorgio Chiellini, a Juventus stalwart, admitted his side were "outplayed in every area of the field" by the Nerazzurri in a 2-0 defeat of the defending champions.
Characterised by extraordinary work-rate and the greater nous offered by coach Antonio Conte - up against his former apprentice Andrea Pirlo - the result was rarely in doubt at San Siro, as Nicolo Barella created one goal for Arturo Vidal and scored the second himself after Alessandro Bastoni's inspired through-ball.
That cherished win came following a brief Inter downturn, which saw an eight-match winning steak ended by two winless games against Sampdoria and Roma. Now, following progress to a mouthwatering Coppa Italia quarter-final against Milan and victory over the Old Lady of Turin, Conte's team could embark on another run of positive results.
League encounters with mid-table outfits Udinese, Benevento, and Fiorentina in the coming weeks provide exactly the kind of prospect enjoyed by free-scoring Romelu Lukaku, Lautaro Martinez and company.
With a seemingly endless supply of goals coming from all quarters, Inter have proved a real goal machine this term - firing home 45 already in Serie A, just before the halfway stage. Only Bayern Munich have registered more in the top five European leagues.
Recent history also holds no surprises as they head to the Dacia Arena, because the Nerazzurri have won nine of their last 11 league meetings with Udinese - not even conceding a solitary goal in the clubs' last five encounters.
In the midst of a tough run of fixtures - including match-ups with Napoli, Atalanta and now Inter, Udinese coach Luca Gotti could be forgiven for breathing a deep sigh of relief when his side eventually eked out a point in Wednesday's previously postponed game against Atalanta.
Despite conceding two thirds of the possession and facing nearly three times as many shots on goal as they could manage themselves, the Zebrette earned a valuable 1-1 draw against their in-form visitors.
Finally, attacking midfielder Roberto Pereyra is coming into some form and bagged his second goal of the season during the week - with both coming in his last four matches, after he was switched to a role in support of struggling centre-forward Kevin Lasagna.
Even so, his underperforming colleagues have still not won a league game since mid-December and have picked up just four points from their eight most recent outings.
All of which leaves Udinese in 15th place - four points above the dreaded dotted line - and Gotti's position in the balance.
The last thing he would have wanted now is a fixture against his club's ultimate bogey team, Inter. The embattled Bianconeri have gained only one point in their last seven home games against the Milan giants and are certainly not fancied to add to that tally this weekend.
Udinese Serie A form: LLDLLD
Inter Milan Serie A form: WWWLDW
Inter Milan form (all competitions): WWLDWW
Despite his regular, arguably unfounded, protestations about squad depth, Inter boss Antonio Conte rarely rotates and may well stick with the XI that soundly beat Juventus last time out.
Alexis Sanchez also has a minor thigh problem, but will most likely start on the sidelines in any case, with Romelu Lukaku and Lautaro Martinez once more joining forces in a fearsome attacking duo.
The hosts are therefore expected to persist with the 3-5-1-1 setup favoured in recent weeks, with Roberto Pereyra starting behind Kevin Lasagna - who has frequently been linked with a move away this month.
Udinese possible starting lineup:
Musso; Becao, Bonifazi, Samir; Larsen, Mandragora, Arslan, De Paul, Zeegelaar; Pereyra; Lasagna
Inter Milan possible starting lineup:
Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Vidal, Young; Martinez, Lukaku
We say: Udinese 1-3 Inter Milan
This is not the time or place for Udinese to break their barren run in Serie A, as Inter have the bit between their teeth at the moment and will prove hard to resist on Saturday.
Conte's men can utilise their ruthless streak to see off a second Bianconeri outfit in as many weeks - keeping closely on the coat-tails of upcoming Coppa Italia opponents Milan.